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The biomimetic strategy of using the cell membrane-coated nanoparticles can retain the physical and chemical properties of the nanoparticles and show the biological characteristics of the source cell membrane, which can further enhance the role of the nanodrug in tumor treatment. A hybrid cell membrane is the fusion of two or more different types of cell membranes. A hybrid cell membrane can endow nanoparticles with multiple biofunctions derived from the source cells compared with a single cell membrane. Hybrid cell membranes provide a foundation to stimulate extensive research into multifunctional biomimetic nano-drug delivery system (NDDS), which is expected to broaden the application of biomimetic nanotechnology in drug delivery systems. In this review paper, the types of hybrid cell membrane used to construct nano-drug delivery systems, the preparation and characterization methods, and cancer treatment research progress in recent years were reviewed.
ABSTRACT
Objective To compare the therapeutic effect of different drug in the treatment of schizophrenia in acute stage.Methods From November 2014 to June 2017,105 patients with acute schizophrenia admitted in Department of Psychiatry of Taiyuan Psychiatric Hospital and Department of Psychiatry of Jiuzhou Dermatological Hospital of Taiyuan were selected in the study.Seventy-five patients were from the Department of Psychiatry,Taiyuan Psychiatric Hospital.Thirty patients were from the Department of Psychiatry,Jiuzhou Dermatology Hospital.The patients were divided into three groups by random number method,with 35 cases in each group.A group was given amisulpride.B group was given olanzapine.C group was given ziprasidone.The PANSS score (positive symptoms,negative symptoms,mental pathological score),curative effect (cured,significantly improved,invalid),adverse events (EPS,akathisia,nausea,rapid heart beat,blurred vision,orthostatic dizziness,weight gain,total adverse events) in the three groups were observed.Results After treatment for 2 weeks,the positive symptoms,negative symptoms,mental pathological score in the three groups were significantly decreased (all P ＜ 0.05).The positive symptoms,negative symptoms,mental pathological score at corresponding period had no statistically significant differences among the three groups (all P ＞ 0.05).There was no statistically significant difference in therapeutic effect among the three groups (P ＞0.05).The occurrence of EPS of C group was significantly lower than that of B group [14.29％ (5/35) vs.40.00％ (14/35),x2 =5.851,P ＜ 0.05].The incidence rate of adverse events of C group was significantly lower than that of A group and B group (x2 =5.833,4.690,all P ＜ 0.05).However,there was no statistically significant difference in the occurrence of adverse events between A group and B group(P ＞ 0.05).Conclusion Amisulpride,olanzapine and ziprasidone in the treatment of acute phase of schizophrenia has good early reaction control and late curative effect.The adverse events of ziprasidone is significantly less than the other two drugs.But patients adopt which kind of drugs also need to formulate specific solutions according to individual circumstance.
ABSTRACT
Objective@#To compare the therapeutic effect of different drug in the treatment of schizophrenia in acute stage.@*Methods@#From November 2014 to June 2017, 105 patients with acute schizophrenia admitted in Department of Psychiatry of Taiyuan Psychiatric Hospital and Department of Psychiatry of Jiuzhou Dermatological Hospital of Taiyuan were selected in the study.Seventy-five patients were from the Department of Psychiatry, Taiyuan Psychiatric Hospital.Thirty patients were from the Department of Psychiatry, Jiuzhou Dermatology Hospital.The patients were divided into three groups by random number method, with 35 cases in each group.A group was given amisulpride.B group was given olanzapine.C group was given ziprasidone.The PANSS score (positive symptoms, negative symptoms, mental pathological score), curative effect (cured, significantly improved, invalid), adverse events (EPS, akathisia, nausea, rapid heart beat, blurred vision, orthostatic dizziness, weight gain, total adverse events) in the three groups were observed.@*Results@#After treatment for 2 weeks, the positive symptoms.negative symptoms, mental pathological score in the three groups were significantly decreased (all P<0.05). The positive symptoms.negative symptoms, mental pathological score at corresponding period had no statistically significant differences among the three groups (all P>0.05). There was no statistically significant difference in therapeutic effect among the three groups (P>0.05). The occurrence of EPS of C group was significantly lower than that of B group [14.29%(5/35) vs.40.00%(14/35), χ2=5.851, P<0.05]. The incidence rate of adverse events of C group was significantly lower than that of A group and B group (χ2=5.833, 4.690, all P<0.05). However, there was no statistically significant difference in the occurrence of adverse events between A group and B group(P>0.05).@*Conclusion@#Amisulpride, olanzapine and ziprasidone in the treatment of acute phase of schizophrenia has good early reaction control and late curative effect.The adverse events of ziprasidone is significantly less than the other two drugs.But patients adopt which kind of drugs also need to formulate specific solutions according to individual circumstance.